Environmental or self-antigens and homotypic interactions result in BCR and Toll-like receptor (TLR) signaling, amplifying the reaction of CLL cells to other alerts with the microenvironment and escalating the activation of anti-apoptotic and proliferation pathways.31,32 Genomic reports have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interactions,... https://bobo360ira3.snack-blog.com/profile