Existence-threatening respiratory melancholy and Loss of life have occurred in kids who received codeine. A lot of the described circumstances occurred next tonsillectomy and/or adenoidectomy and plenty of of the kids experienced proof of being extremely-fast metabolizers of codeine as a consequence of a cytochrome P450 (CYP) 2D6 polymorphism (see https://wockusa.com/product/actavis-promethazine-codeine/